|
|
S-adenosyl-L-homocysteine + H2O <=> L-homocysteine + adenosine
|
3.3.1.1
adenosylhomocysteinase
|
–
|
BMK
|
|
BRENDA:
BR16046
KEGG:
R00192
MetaCyc:
ADENOSYLHOMOCYSTEINASE-RXN
SABIO-RK:
738;
8119
|
|
|
|
H2O + L-homocysteine <=> Sulfide + 2-oxobutyrate + NH3
|
4.4.1.1
cystathionine gamma-lyase
4.4.1.11
methionine gamma-lyase
4.4.1.2
homocysteine desulfhydrase
|
–
–
–
|
MK
|
|
BRENDA:
BR3441;
BS368485
KEGG:
R01283
MetaCyc:
HOMOCYSTEINE-DESULFHYDRASE-RXN
SABIO-RK:
1499;
7311
|
|
|
|
L-cystathionine + H2O <=> L-homocysteine + pyruvate + NH3
|
2.5.1.48
cystathionine gamma-synthase
3.5.1.61
mimosinase
4.2.1.22
cystathionine beta-synthase
4.4.1.1
cystathionine gamma-lyase
4.4.1.13
cysteine-S-conjugate beta-lyase
4.4.1.28
L-cysteine desulfidase
4.4.1.3
dimethylpropiothetin dethiomethylase
|
–
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR3446
KEGG:
R01286
MetaCyc:
CYSTATHIONINE-BETA-LYASE-RXN
SABIO-RK:
1500;
1501
|
|
|
|
L-homocysteine + betaine <=> L-methionine + N,N-dimethylglycine
|
2.1.1.5
betaine---homocysteine S-methyltransferase
|
–
|
BMK
|
|
BRENDA:
BR40558
KEGG:
R02821
MetaCyc:
2.1.1.5-RXN
SABIO-RK:
2687
|
|
|
|
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine <=> tetrahydropteroyl-Glu3 + L-methionine
|
2.1.1.13
methionine synthase
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
|
–
–
|
BMK
|
|
BRENDA:
BR40568
KEGG:
R04405
MetaCyc:
HOMOCYSMET-RXN
|
|
|
|
S-methyl-L-methionine + L-homocysteine <=> H+ + L-methionine
|
2.1.1.10
homocysteine S-methyltransferase
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
2.1.1.5
betaine---homocysteine S-methyltransferase
|
–
–
–
|
M
|
|
BRENDA:
BR40572
KEGG:
R11063
MetaCyc:
MMUM-RXN
SABIO-RK:
13306
|
|
|
|
L-serine + L-homocysteine <=> L-cystathionine + H2O
|
2.5.1.47
cysteine synthase
4.2.1.22
cystathionine beta-synthase
|
–
–
|
BMK
|
|
BRENDA:
BR406
KEGG:
R01289;
R01290
MetaCyc:
CYSTATHIONINE-BETA-SYNTHASE-RXN
SABIO-RK:
1504;
1505
|
|
|
|
L-homocysteine + dimethylsulfonioacetate <=> H+ + L-methionine + methylthioacetate
|
2.1.1.3
thetin---homocysteine S-methyltransferase
|
–
|
|
|
BRENDA:
BR43892
KEGG:
R04153
MetaCyc:
2.1.1.3-RXN
|
|
|
|
S-ribosylhomocysteine <=> L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione
|
4.4.1.21
S-ribosylhomocysteine lyase
|
–
|
BMK
|
|
BRENDA:
BR48539;
BS371157
KEGG:
R01291
MetaCyc:
RIBOSYLHOMOCYSTEINASE-RXN
SABIO-RK:
6873
|
|
|
|
L-homocysteine <=> Sulfide + 2-aminobut-2-enoate + H+
|
4.4.1.2
homocysteine desulfhydrase
|
–
|
|
|
BRENDA:
BR51160
KEGG:
R08633
MetaCyc:
RXN-15148
|
|
|
|
L-cystathionine <=> 2-aminoacrylate + L-homocysteine
|
4.4.1.13
cysteine-S-conjugate beta-lyase
|
–
|
M
|
|
BRENDA:
BR51162
MetaCyc:
RXN-15131
|
|
|
|
O-acetyl-L-serine + L-homocysteine <=> L-cystathionine + acetate + H+
|
2.5.1.134
cystathionine beta-synthase (O-acetyl-L-serine)
2.5.1.47
cysteine synthase
4.2.1.22
cystathionine beta-synthase
|
–
–
–
|
K
|
|
BRENDA:
BR51757
KEGG:
R10305
MetaCyc:
RXN-17600
SABIO-RK:
15389
|
|
|
|
Sulfide + L-aspartate_4-semialdehyde + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> L-homocysteine + H2O + oxidized_ferredoxin
|
2.8.1.16
L-aspartate semialdehyde sulfurtransferase
|
–
|
MK
|
|
BRENDA:
BR52927
KEGG:
R12505
MetaCyc:
RXN-19380
|
|
|
|
S-Inosyl-L-homocysteine + H2O <=> Inosine + L-homocysteine
|
3.13.1.9
S-inosyl-L-homocysteine hydrolase
3.3.1.1
adenosylhomocysteinase
3.3.1.B1
|
–
–
–
|
|
|
BRENDA:
BR53052
KEGG:
R12588
MetaCyc:
RXN-20698
SABIO-RK:
14986
|
|
|
|
S-adenosyl-L-methionine + L-homocysteine <=> L-methionine + S-adenosyl-L-homocysteine + H+
|
2.1.1.10
homocysteine S-methyltransferase
2.1.1.13
methionine synthase
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
2.1.1.280
selenocysteine Se-methyltransferase
|
–
–
–
–
|
BK
|
|
BRENDA:
BS289526;
BS419713
KEGG:
R00650
MetaCyc:
HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN
SABIO-RK:
1035
|
|
|
|
O-succinyl-L-homoserine + Sulfide <=> H+ + L-homocysteine + succinate
|
2.5.1
2.5.1.48
cystathionine gamma-synthase
2.5.1.49
O-acetylhomoserine aminocarboxypropyltransferase
|
–
–
–
|
K
|
|
BRENDA:
BS354328
KEGG:
R01288
MetaCyc:
RXN-9384
|
|
|
|
O-acetyl-L-homoserine + Sulfide <=> H+ + L-homocysteine + acetate
|
2.5.1.49
O-acetylhomoserine aminocarboxypropyltransferase
|
–
|
BMK
|
|
BRENDA:
BS354674
KEGG:
R01287
MetaCyc:
ACETYLHOMOSER-CYS-RXN
|
|
|
|
L-cysteine + L-homocysteine <=> L-cystathionine + Sulfide
|
2.5.1.47
cysteine synthase
4.2.1.22
cystathionine beta-synthase
4.4.1.1
cystathionine gamma-lyase
|
–
–
–
|
M
|
|
BRENDA:
BS409645
MetaCyc:
RXN66-562
SABIO-RK:
7280
|
|
|
|
L-homocysteine <=> Sulfide + L-homolanthionine
|
4.4.1.1
cystathionine gamma-lyase
|
–
|
M
|
|
BRENDA:
BS412268
MetaCyc:
RXN-14632
SABIO-RK:
13946
|
|
|
|
homocysteine_thiolactone + H2O <=> L-homocysteine + H+
|
3.1.1.81
quorum-quenching N-acyl-homoserine lactonase
3.4.22.40
bleomycin hydrolase
|
–
–
|
|
|
BRENDA:
BS417985
MetaCyc:
RXN-21218
SABIO-RK:
12769
|
|
|
|
L-homocystine + glutathione <=> GSSG + L-homocysteine
|
1.8.4.1
glutathione---homocystine transhydrogenase
|
–
|
K
|
|
BRENDA:
BR37027
KEGG:
R01110;
R01292
MetaCyc:
1.8.4.1-RXN
|
|
|
|
L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate
|
2.1.1.13
methionine synthase
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
|
–
–
|
BMK
|
|
BRENDA:
BR40552
KEGG:
R00946
MetaCyc:
HOMOCYSMETB12-RXN
SABIO-RK:
1260
|
|
|
|
O-phospho-L-homoserine + S2- <=> L-homocysteine + phosphate
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
|
|
BRENDA:
BS354373
SABIO-RK:
13008
|
|
|
|
3-deazaadenosine + L-homocysteine <=> S-(3-deazaadenosyl)-L-homocysteine
|
3.3.1.1
adenosylhomocysteinase
|
–
|
|
|
BRENDA:
BS94867
SABIO-RK:
8116
|
|
|
|
O-acetyl-L-homoserine + thiosulfate + thioredoxin + H+ <=> L-homocysteine + sulfite + thioredoxin_disulfide + acetate
|
not assigned
|
–
|
K
|
|
KEGG:
R02026
|
|
|
|
L-valine + L-tryptophan + L-methionine + NADPH + H+ <=> N-methyl-L-valyl-L-tryptophanol + L-homocysteine + H2O + NADP+
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN-17004
|
|
|
|
methylcob(III)alamin-[methionine_synthase] + L-homocysteine <=> cob(I)alamin-[methionine_synthase] + L-methionine + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-21538
|
|
|
|
L-homocysteine + H2O + O2 <=> 4-Mercapto-2-oxobutanoate + NH3 + H2O2
|
1.4.3.2
L-amino-acid oxidase
|
–
|
|
|
BRENDA:
BS259030
|
|
|
|
2-oxosuccinamic_acid + L-homocysteine <=> L-asparagine + 4-Mercapto-2-oxobutanoate
|
2.6.1.14
asparagine---oxo-acid transaminase
|
–
|
|
|
BRENDA:
BS354183
|
|
|
|
2 L-lysine + L-homocystine <=> GSSG + 2 L-homocysteine
|
1.8.4.1
glutathione---homocystine transhydrogenase
|
–
|
|
|
BRENDA:
BS440544
|
|
|
|
S-adenosyl-L-methionine + adenine_in_5''-UACACUCGAUCU-GGACU-AAAGCUGCUC <=> L-homocysteine + 5''-UACACUCGAUCU-GG-(N6-methyl)ACU-AAAGCUGCUC
|
2.1.1.348
mRNA m6A methyltransferase
|
–
|
|
|
BRENDA:
BS443893
|
|
|
|
DL-homocysteine_thiolactone + H2O <=> L-homocysteine
|
3.1.1.25
1,4-lactonase
|
–
|
|
|
BRENDA:
BS447603
|
|
|
|
L-homocysteine + KCN <=> gamma-cyano-alpha-aminobutyric_acid + Sulfide
|
2.5.1.49
O-acetylhomoserine aminocarboxypropyltransferase
|
–
|
|
|
BRENDA:
BS380000
|
|
|
|
L-homoserine + Sulfide <=> L-homocysteine + H2O
|
2.5.1.49
O-acetylhomoserine aminocarboxypropyltransferase
|
–
|
|
|
BRENDA:
BS380001
|
|
|
|
S-adenosyl-L-ethionine + L-homocysteine <=> S-adenosyl-L-homocysteine + L-ethionine
|
2.1.1.10
homocysteine S-methyltransferase
|
–
|
|
|
BRENDA:
BS289616
|
|
|
|
(R,S)-S-adenosylmethionine + L-homocysteine <=> L-methionine + S-adenosyl-L-homocysteine
|
2.1.1.10
homocysteine S-methyltransferase
|
–
|
|
|
BRENDA:
BS419699
|
|
|
|
O-acetyl-L-homoserine + L-homocysteine <=> L-homolanthionine + acetate
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
|
|
BRENDA:
BS354367
|
|
|
|
O-Succinyl-L-serine + L-homocysteine <=> succinate + L-cystathionine
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
|
|
BRENDA:
BS354331
|
|
|
|
Sulfide + L-homocysteine + ubiquinone <=> homocysteine_persulfide + ubiquinol
|
1.8.5.4
bacterial sulfide:quinone reductase
|
–
|
|
|
BRENDA:
BS437921
|
|
|
|
L-homocysteine + alkanethiol <=> S-alkylhomocysteine
|
4.4.1.11
methionine gamma-lyase
|
–
|
|
|
BRENDA:
BS19049
|
|
|
|
L-cysteine + L-homocystine <=> L-cystine + 2 L-homocysteine
|
1.8.4.1
glutathione---homocystine transhydrogenase
|
–
|
|
|
BRENDA:
BS441243
|
|
|
|
L-cysteine + L-homocysteine <=> L-cystathionine + acetate
|
2.5.1.47
cysteine synthase
4.2.1.22
cystathionine beta-synthase
|
–
–
|
|
|
BRENDA:
BS445596
|
|
|
|
L-homocysteine <=> D-homocysteine
|
5.1.1.10
amino-acid racemase
|
–
|
|
|
BRENDA:
BS843
|
|
|
|
O-succinyl-L-homoserine + Na2S <=> L-homocysteine + Sodium_succinate
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
|
|
BRENDA:
BS354325
|
|
|
|
O-acetyl-L-homoserine + S2- <=> L-homocysteine + acetate
|
2.5.1.48
cystathionine gamma-synthase
2.5.1.49
O-acetylhomoserine aminocarboxypropyltransferase
|
–
–
|
|
|
BRENDA:
BS354345
|
|
|
|
ATP + L-glutamate + L-homocysteine <=> ADP + phosphate + gamma-L-Glu-L-homocysteine
|
6.3.2.2
glutamate---cysteine ligase
|
–
|
|
|
BRENDA:
BS514
|
|
|
|
5-methyltetrahydropteroylmonoglutamate + L-homocysteine <=> tetrahydrofolate + L-methionine
|
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
|
–
|
|
|
BRENDA:
BS289580
|
|
|
|
N5-methyltetrahydropteroylheptaglutamate + L-homocysteine <=> tetrahydropteroylheptaglutamate + L-methionine
|
2.1.1.13
methionine synthase
|
–
|
|
|
BRENDA:
BS289524
|
|
|
|
L-methionine + nicotinamide <=> L-homocysteine + N1-methylnicotinamide
|
2.1.1.1
nicotinamide N-methyltransferase
|
–
|
|
|
BRENDA:
BS370285
|
|
|
|
5-methyltetrahydropteroyl-gamma-glutamylglutamate + L-homocysteine <=> tetrahydrofolate-Glu + L-methionine
|
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
|
–
|
|
|
BRENDA:
BS387620
|
|
|
|
N5-methyltetrahydropteroylpentaglutamate + L-homocysteine <=> Tetrahydropteroylpentaglutamate + L-methionine
|
2.1.1.13
methionine synthase
|
–
|
|
|
BRENDA:
BS289523
|
|
|
|
5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine <=> tetrahydropteroyl-gamma-glutamyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
|
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
|
–
|
|
|
BRENDA:
BS451810
|
|
|
|
S-methyl-L-methionine + L-homocysteine <=> L-methionine + Se-methyl-L-homocysteine
|
2.1.1.280
selenocysteine Se-methyltransferase
|
–
|
|
|
BRENDA:
BS454643
|
|
|
|
L-homoserine + L-homocysteine <=> L-homolanthionine
|
4.4.1.1
cystathionine gamma-lyase
|
–
|
|
|
BRENDA:
BS19026
|
|
|
|
L-2-aminoadipate + L-homocysteine + L-valine + ATP <=> N-(5-amino-5-carboxypentanoyl)-L-homocysteinyl-D-valine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
|
|
BRENDA:
BS289203
|
|
|
|
L-homocysteine + phenylpyruvate <=> 4-Mercapto-2-oxobutanoate + L-phenylalanine
|
2.6.1.64
glutamine---phenylpyruvate transaminase
|
–
|
|
|
BRENDA:
BS356842
|
|
|
|
Na2S + O-phospho-L-homoserine <=> Sodium_phosphate + L-homocysteine
|
2.5.1.48
cystathionine gamma-synthase
|
–
|
|
|
SABIO-RK:
13258
|
|